Journal of Liver Cancer

Young Myoung Moon

5 Articles

Excellent Response to Hepatic Arterial Infusional Chemotherapy in Advanced Hepatocellular Carcinoma with Portal Vein Thrombosis: Keun-Ho Lee, Ja Kyung Kim, Kwang-Hyub Han, Jong Tae Lee, Do Youn Lee, Jong Yoon Won, Hyun Woong Lee, Hwa Sook Kim, Ki Tae Yoon, Sang Hoon Ahn, Chae Yoon Chon, Young Myoung Moon; Journal of the Korean Liver Cancer Study Group. 2006;6(1):42-46. Published online June 30, 2006

Abstract PDF: There is no treatment of curative aim in advanced hepatocellular carcinoma (HCC) with portal vein thrombosis (PVT), which is associated with poor prognosis. Albeit one of the treatment options is intra-arterial infusional chemotherapy, its therapeutic efficacy was minimal. In this report, we present an unusual case of a patient with favorable result after intra-arterial infusional chemotherapy. This patient was HBV carrier and diagnosed having HCC of stage IVb (T4N0M1) with right PVT on February 1999. Direct right adrenal gland and right kidney invasion and numerous intrahepatic metastases were also noted. The serum AFP level showed more than 60,000 ng/mL, and the Child-Pugh score was 5 (class A). The patient received three sessions of intra-arterial 5-fluorouracil (5-FU) and cisplatin combination chemotherapy and two additional sessions of systemic (5-FU) chemotherapy combined with intra-arterial cisplatin infusion. After total 5 sessions of combination chemotherapy, follow-up CT scan revealed grossly total necrosis of main HCC and numerous intrahepatic metastases, without evidence of viable portion in July 1999. The AFP level decreased to 79.4 ng/mL. The latest CT scan taken in November 2005 also showed no evidence of recurrence. It is noteworthy that the patient with advanced HCC with PVT showed complete remission only after 5 sessions of intra-arterial chemotherapy and the status of complete remission is maintained for more than 76 months.

A Case of Hepatocellular Carcinoma Araising from Dysplastic Nodule: Sang Hoon Ahn, Yong Nyun Park, Yoon Jae Kim, Jae Yoon Chon, Young Myoung Moon, Kwang Hyub Han; Journal of the Korean Liver Cancer Study Group. 2003;3(1):83-86. Published online July 31, 2003

Abstract PDF: Early diagnosis is invaluable for the treatment of hepatocellular carcinoma (HCC). However, it does not seem to be easy to differentiate between HCC arising in dysplastic nodule and dysplastic nodule without HCC foci by radiologic findings. We report a case of HCC arising in dysplastic nodule, which is confirmed by pathological examination of explanted liver.

A Case of Hepatocellular Carcinoma with Bile Duct Invasion: Seung Min Bang, Hye Won Chung, Jae Youn Cheong, Chung Ryul Lee, Kun Hoon Song, Kwang Hyub Han, Chae Yoon Cheon, Young Myoung Moon, Sung Il Park, Do Yun Lee, Jong Tae Lee; Journal of the Korean Liver Cancer Study Group. 2001;1(1):85-88. Published online June 30, 2001

Abstract PDF: A 52 year-old female patient with liver cirrhosis admitted due to icteric skin color for 3 weeks. Four months ago, she had been diagnosed as hepatocellular carcinoma(HCC), and treated with transarterial chemoembolization(TACE) at another hospital. Physical findings revealed that she had icteric sclera without ascites or palpable hepatosplenomegaly. Total bilirubin was 6.0mg/dL, ALT/AST was 117/111 IU/L. Computed tomography showed 3cm sized nodular mass involving left lateral segment of the liver and left intrahepatic bile duct. Endoscopic retrograde cholangiopancreatography(ERCP) revealed filling defect of left intrahepaitc duct and common hepatic duct, suggesting left intrahepatic duct and common hepatic duct invasion of HCC. After endoscopic retrograde biliary drainage(ERBD) with stent insertion, total bilirubin was decreased and clinical symptoms were improved. She was treated with TACE using adriamycin after ERBD. Thereafter, she was prescribed oral 5-fluorouracil and treated with external radiotherapy(4,500cGy). Five months later after the treatment, CT scan showed decrease in tumor size, and jaundice was improved as well.

A Case of Hepatocellular Carcinoma with Dramatic Therapeutic Response in Stage Ⅳa (T4N0M0): Hye Won Chung, Jae Youn Cheong, Kun Hoon Song, Kwang Hyub Han, Young Myoung Moon, Byoung Ro Kim, Jin Sil Seong, Myoung Jin Kim, Do Yun Lee, Young Nyun Park; Journal of the Korean Liver Cancer Study Group. 2001;1(1):89-92. Published online June 30, 2001

Abstract PDF: A 52 year-old-female patient was admitted due to right upper quadrant abdominal pain and right shoulder pain for 1 month. She had no history of previous medical problem before admission. At admission, physical findings revealed that she had 2 FB palpable hepatomegaly and others were not remarkable. Laboratory findings revealed that HBsAg and HBeAG were positive enhanced at arterial phase involving entire right lobe and S4, and thrombus at main portal vein. Clinically she was diagnosed advanced hepatocellular carcinoma(HCC) and TNM stage was T4N0M0, stage Ⅳa. She was treated with transarterial chemoembolization(TACE) for 2 cycles and radiation therapy. After TACE and radiation therapy, the tumor size decreased and the main portal vein thrombus was disappeared. Then, she underwent extended right lobectomy of the liver. Pathology of operative specimen revealed well-encapsulated HCC at Edmonsons grade Ⅱ, near total necrosis. Normal liver tissue showed sinusoidal congestion, mild periportal fibrosis, and veno-occlusive disease. Two years after the operation, there had been no sign of recurrence and follow-up CT scan showed sign of recurrence at S2. He underwent percutaneous Holmium injection 3 times and TACE 4 times, and so far he survived for 6 years and 10 months. He is currently under observation at out patient department.

Case of Advanced Hepatocellular Carcinoma (TNM Satge Ⅳa) with Portal Vein Invasion Treated with Intraarterial Chemotherapy and Transarterial Chemoembolization/Chemoinfusion: Chul Kim, Chae Yoon Chon, Jae Yeon Chung, Gun Hoon Song, Young Joon Yun, Tae Ik Chang, Kwang Hyup Han, Young Myoung Moon, Do Yun Lee, Jong Tae Lee; Journal of the Korean Liver Cancer Study Group. 2001;1(1):93-97. Published online June 30, 2001

Abstract PDF: A 75 year-old-male patient with liver cirrhosis was admitted due to right upper quadrant abdominal pain for 6 months. One month ago, abdominal CT showed a space occupying lesion in the liver. On admission, physical examination revealed mild tenderness on right upper quadrant without jaundice and palpable liver about 3 FB on RLCM. Laboratory findings showed that HBsAg and anti-HCV were negative. AFP was 2,395 ng/ml. Other laboratory findings were within normal range. Abdominal CT showed a huge encapsulated hepatic mass at right lobe of the liver with internal hemorrhage and portal vein thrombosis, which was compatible with advanced hepatocellular carcinoma (stage Ⅳa). Superior mesenteric arteriogram showed right portal vein obstruction. Celiac and hepatic arteriograms revealed huge hypervascular mass at right lobe of the liver. He was treated with intraarterial cisplatin (DDP) infusion. After the 7th intraarterial DDP infusion and the 2nd transarterial chemoembolization (TACE)/transarterial chemoinfusion (TACI), the patient is now without evidence of recurrence for 19 months, and his general condition is good. He is under close observation at out patient clinic.